Synthesis and Antimicrobial Activity of New Thiazolo/Thiazinopyrimidino [6, 5-C] Benzocycloheptenes
V Peesapati, K Anuradha… - Synthetic …, 1999 - Taylor & Francis
V Peesapati, K Anuradha, P Sreelakshmi
Synthetic Communications, 1999•Taylor & FrancisAbstract Synthesis of 2-memyl-8-phenyl-5) 6, 7, 8, 10, 11-hexahydrobenzo [6, 7]-cyclohepta
[d][1, 3] thiazolo [3, 2-a] pyrimidin-10-ones (4a-g), 2-methyl-8-phenyl-5, 6, 7, 8, 11, 12-
hexahydro-10H-bemzo [6′, 7′] cyclohepta [4, 5] pyrimido [2, 1-b][1, 3]-thiazin-10-ones (6a-
g) and 2, 11-dimethyl-8-phenyl-5, 6, 7, 8, 10, 11-hexahydro-benzo [6, 7] cyclohepta [d][1, 3]
thiazolo [3, 2-a] pyrimidin-10-ones (8a-g) have been described. A number of compounds
show promising antimicrobial acitity.
[d][1, 3] thiazolo [3, 2-a] pyrimidin-10-ones (4a-g), 2-methyl-8-phenyl-5, 6, 7, 8, 11, 12-
hexahydro-10H-bemzo [6′, 7′] cyclohepta [4, 5] pyrimido [2, 1-b][1, 3]-thiazin-10-ones (6a-
g) and 2, 11-dimethyl-8-phenyl-5, 6, 7, 8, 10, 11-hexahydro-benzo [6, 7] cyclohepta [d][1, 3]
thiazolo [3, 2-a] pyrimidin-10-ones (8a-g) have been described. A number of compounds
show promising antimicrobial acitity.
Abstract
Synthesis of 2-memyl-8-phenyl-5) 6,7,8,10,11-hexahydrobenzo[6,7]-cyclohepta[d][1,3]thiazolo[3,2-a]pyrimidin-10-ones (4a-g), 2-methyl-8-phenyl-5,6,7,8,11,12-hexahydro-10H-bemzo[6′,7′]cyclohepta[4,5]pyrimido[2,1-b][1,3]-thiazin-10-ones (6a-g) and 2,11-dimethyl-8-phenyl-5,6,7,8,10,11-hexahydro-benzo[6,7]cyclohepta[d][1,3]thiazolo[3,2-a]pyrimidin-10-ones (8a-g) have been described. A number of compounds show promising antimicrobial acitity.
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