Synthesis and Lipase-Catalyzed Enantiotope Selective Acetylation of 2-Benzoyloxy-1, 3-propanediol
V Bodai, L Novak, L Poppe - Synlett, 1999 - thieme-connect.com
V Bodai, L Novak, L Poppe
Synlett, 1999•thieme-connect.com… Abstract: Preparation and porcine pancreatic lipase (PPL)-catalyzed enantiotope
selective acetylation of the prochiral 2-benzoyloxy-1,3-propanediol (1a) is described. The
reaction with PPL and vinyl acetate gave monoacetate (2a) of 96 % ee … Biocatalytical
preparation of these chiral C3 units were carried out either by enantiomer selective or
enantiotope selective manner. The kinetic resolution of racemic glycerol derivatives such as
glycerol acetonide5,6 , glycerol2,3-carbonate 7 provided moderate selectivity and 50 …
selective acetylation of the prochiral 2-benzoyloxy-1,3-propanediol (1a) is described. The
reaction with PPL and vinyl acetate gave monoacetate (2a) of 96 % ee … Biocatalytical
preparation of these chiral C3 units were carried out either by enantiomer selective or
enantiotope selective manner. The kinetic resolution of racemic glycerol derivatives such as
glycerol acetonide5,6 , glycerol2,3-carbonate 7 provided moderate selectivity and 50 …
Abstract
Preparation and porcine pancreatic lipase (PPL)-catalyzed enantiotope selective acetylation of the prochiral 2-benzoyloxy-1, 3-propanediol (1a) is described. The reaction with PPL and vinyl acetate gave monoacetate (2a) of 96% ee
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