[引用][C] Synthesis and structural study of a new series of 2‐methylsulfanyl‐tetrahydropyrimidines from β‐alkoxyvinyl trihalomethyl ketones
N Zanatta, CC Madruga, PC Marisco… - Journal of …, 2008 - Wiley Online Library
Journal of Heterocyclic Chemistry, 2008•Wiley Online Library
This work describes the synthesis of a novel series of 2‐methylsulfanyl‐
tetrahydropyrimidines, from the cyclocondensation reaction of β‐alkoxyvinyl trihalomethyl
ketones with 2‐methyl‐2‐thiopseudourea sulfate, in good yields. A detailed 1H‐and 13C‐
NMR study was performed on the 2‐methylsulfanyl‐tetrahydropyrimidines obtained and 3D
structures were proposed based on AM1 calculations supported by 1H NMR coupling
constants and NOESY experiments.
tetrahydropyrimidines, from the cyclocondensation reaction of β‐alkoxyvinyl trihalomethyl
ketones with 2‐methyl‐2‐thiopseudourea sulfate, in good yields. A detailed 1H‐and 13C‐
NMR study was performed on the 2‐methylsulfanyl‐tetrahydropyrimidines obtained and 3D
structures were proposed based on AM1 calculations supported by 1H NMR coupling
constants and NOESY experiments.
Abstract
This work describes the synthesis of a novel series of 2‐methylsulfanyl‐tetrahydropyrimidines, from the cyclocondensation reaction of β‐alkoxyvinyl trihalomethyl ketones with 2‐methyl‐2‐thiopseudourea sulfate, in good yields. A detailed 1H‐ and 13C‐NMR study was performed on the 2‐methylsulfanyl‐tetrahydropyrimidines obtained and 3D structures were proposed based on AM1 calculations supported by 1H NMR coupling constants and NOESY experiments.
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