A new type of inhibitor of tubulin polymerization was discovered on the basis of the
combretastatin molecular skeleton. The lead compounds in this series, compounds 6 and 7,
strongly inhibited tubulin polymerization in vitro and significantly arrested cells at the G2/M
phase. Compounds 6 and 7 yielded 50-to 100-fold lower IC50 values than did
combretastatin A-4 against Colo 205, NUGC3, and HA22T human cancer cell lines as well
as similar or greater growth inhibitory activities than did combretastain A-4 against DLD-1 …

… Title: Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives
as antimitotic agents … Relation: Abstracts of Papers of the American Chemical Society.
2002 Aug;224:076-MEDI. …