Synthesis of cyclic, multivalent Arg-Gly-Asp using sequential thiol–ene/thiol–yne photoreactions
AA Aimetti, KR Feaver, KS Anseth - Chemical communications, 2010 - pubs.rsc.org
AA Aimetti, KR Feaver, KS Anseth
Chemical communications, 2010•pubs.rsc.orgA unique method has been developed for the formation of multivalent cyclic peptides. This
procedure exploits on-resin peptide cyclization using a photoinitiated thiol–ene click
reaction and subsequent clustering using thiol–yne photochemistry. Both reactions utilize
the sulfhydryl group on natural cysteine amino acids to participate in the thiol-mediated
reactions.
procedure exploits on-resin peptide cyclization using a photoinitiated thiol–ene click
reaction and subsequent clustering using thiol–yne photochemistry. Both reactions utilize
the sulfhydryl group on natural cysteine amino acids to participate in the thiol-mediated
reactions.
A unique method has been developed for the formation of multivalent cyclic peptides. This procedure exploits on-resin peptide cyclization using a photoinitiated thiol–ene click reaction and subsequent clustering using thiol–yne photochemistry. Both reactions utilize the sulfhydryl group on natural cysteine amino acids to participate in the thiol-mediated reactions.
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