[HTML][HTML] Synthesis of magnetic bio-nanocomposites for drug release and adsorption applications
South African Journal of Chemical Engineering, 2022•Elsevier
Abstract Aims: Synthesis of nanocarrier Fe 3 O 4/silica-starch/PNVCL for drug delivery and
Fe 3 O 4/GO-starch for antibiotic removal applications Background: In the first part, the new
magnetic nanocomposite including Fe 3 O 4 nanoparticles coated with silica, anchored
starch nanoparticles, and poly (N-vinylcaprolactam) and then, loaded by acetazolamide. In
the second part, magnetic starch nanocomposites were synthesized and modified with
graphene oxide. Methods: The drug loading, release and intrinsic cytotoxicity were …
Fe 3 O 4/GO-starch for antibiotic removal applications Background: In the first part, the new
magnetic nanocomposite including Fe 3 O 4 nanoparticles coated with silica, anchored
starch nanoparticles, and poly (N-vinylcaprolactam) and then, loaded by acetazolamide. In
the second part, magnetic starch nanocomposites were synthesized and modified with
graphene oxide. Methods: The drug loading, release and intrinsic cytotoxicity were …
Abstract
Aims: Synthesis of nanocarrier Fe3O4/silica-starch/PNVCL for drug delivery and Fe3O4/GO-starch for antibiotic removal applications
Background: In the first part, the new magnetic nanocomposite including Fe3O4 nanoparticles coated with silica, anchored starch nanoparticles, and poly(N-vinylcaprolactam) and then, loaded by acetazolamide. In the second part, magnetic starch nanocomposites were synthesized and modified with graphene oxide.
Methods: The drug loading, release and intrinsic cytotoxicity were measured. Also, the potential of Fe3O4/GO-starch as an adsorbent to remove cephalexin antibiotics from aqueous solutions was evaluated.
Result: In the first part, the maximum drug adsorption was occurred at pH = 7 on the nanocarrier and the Langmuir model looks more suitable for describing the adsorption process at room temperature. The second study showed that the maximum adsorption of cephalexin at pH 4 for magnetic nanocomposites in good agreement with the Freundlich model and the adsorption kinetics followed the quasi-quadratic model.
Conclusion: It seems that the prepared nanocarrier Fe3O4/silica-starch/PNVCL can be utilized as a promising candidate for drug delivery. Also, magnetic nanocomposites of Fe3O4/GO-starch can be used as suitable and inexpensive adsorbents in cephalexin removal.
Elsevier
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