Synthesis of novel diflunisal hydrazide–hydrazones as anti-hepatitis C virus agents and hepatocellular carcinoma inhibitors
S Şenkardeş, N Kaushik-Basu, I Durmaz… - European journal of …, 2016 - Elsevier
European journal of medicinal chemistry, 2016•Elsevier
Highlights•We synthesized new diflunisal hydrazide–hydrazones.•We investigated their
activity against hepatitis C virus (HCV).•Some compounds exhibited strong inhibition against
HCV 1b and 2a genotypes.•The hydrazide–hydrazone derivatives were shown to inhibit
cellular growth of liver cancer cells.
activity against hepatitis C virus (HCV).•Some compounds exhibited strong inhibition against
HCV 1b and 2a genotypes.•The hydrazide–hydrazone derivatives were shown to inhibit
cellular growth of liver cancer cells.
Highlights
- We synthesized new diflunisal hydrazide–hydrazones.
- We investigated their activity against hepatitis C virus (HCV).
- Some compounds exhibited strong inhibition against HCV 1b and 2a genotypes.
- The hydrazide–hydrazone derivatives were shown to inhibit cellular growth of liver cancer cells.
Elsevier
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