Synthesis of novel fused azecine ring systems through application of the tert-amino effect
Novel fused azecine ring systems were synthesized via the microwave-assisted thermal
isomerization of terphenyl or biphenyl-pyridazine compounds possessing a vinyl and a tert-
amino group, through application of a new extension of the tert-amino effect. Substrates for
the ring closure were prepared from ortho-dihalobenzene or pyridazinone by consecutive
Suzuki couplings with ortho-sec-amino-and formylphenylboronic acids, followed by
Knoevenagel condensation of the aldehydes obtained.
isomerization of terphenyl or biphenyl-pyridazine compounds possessing a vinyl and a tert-
amino group, through application of a new extension of the tert-amino effect. Substrates for
the ring closure were prepared from ortho-dihalobenzene or pyridazinone by consecutive
Suzuki couplings with ortho-sec-amino-and formylphenylboronic acids, followed by
Knoevenagel condensation of the aldehydes obtained.
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