Synthesis of quinoline coupled [1, 2, 3]-triazoles as a promising class of anti-tuberculosis agents
A series of quinoline coupled 1, 2, 3-triazoles compounds have been synthesized by 'click
chemistry'from azidomethyl quinoline with different alkynes. The efficiency and fidelity of the
Cu (I)-catalyzed azide–alkyne reaction are substantiated by good yields and exclusive
formation of the expected 1, 4-disubstituted triazole product. All the synthesized compounds
were screened for anti-tubercular activity against Mycobacterium tuberculosis H37Rv by
luciferase reporter phage (LRP) assay. Quinoline coupled triazole sugar hybrid, 20 is the …
chemistry'from azidomethyl quinoline with different alkynes. The efficiency and fidelity of the
Cu (I)-catalyzed azide–alkyne reaction are substantiated by good yields and exclusive
formation of the expected 1, 4-disubstituted triazole product. All the synthesized compounds
were screened for anti-tubercular activity against Mycobacterium tuberculosis H37Rv by
luciferase reporter phage (LRP) assay. Quinoline coupled triazole sugar hybrid, 20 is the …
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