Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents
Three novel series of 2′, 4′-difluoro-4-hydroxybiphenyl-3-carboxylic acid derivatives
namely 4-substituted-1, 2, 4-triazoline-3-thiones (4a–g); 2-substituted-1, 3, 4-thiadiazoles
(5a–g) and 2-substituted-1, 3, 4-oxadiazoles (6a–g) have been synthesized. Twenty-one of
the newly synthesized compounds were tested against various bacteria, fungi, yeast species
and virus. In addition, we have replaced the carboxylic acid group of diflunisal with
heterocycles and the anti-inflammatory activity of heterocycles reported here. Compound …
namely 4-substituted-1, 2, 4-triazoline-3-thiones (4a–g); 2-substituted-1, 3, 4-thiadiazoles
(5a–g) and 2-substituted-1, 3, 4-oxadiazoles (6a–g) have been synthesized. Twenty-one of
the newly synthesized compounds were tested against various bacteria, fungi, yeast species
and virus. In addition, we have replaced the carboxylic acid group of diflunisal with
heterocycles and the anti-inflammatory activity of heterocycles reported here. Compound …
Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents
E TATAR - 2007 - openaccess.marmara.edu.tr
Abstract Three novel series of 2', 4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid derivatives
namely 4-substituted-1, 2, 4-triazoline-3-thiones (4a-g); 2-substituted-1.3. 4-thiadiazoles (5a-
g) and 2-substituted-1, 3, 4-oxadiazoles (6a-g) have been synthesized. Twenty-one of the
newly synthesized compounds were tested against various bacteria, fungi, yeast species
and virus. In addition, we have replaced the carboxylic acid group of diflunisal with
heterocycles and the anti-inflammatory activity of heterocycles reported here. Compound …
namely 4-substituted-1, 2, 4-triazoline-3-thiones (4a-g); 2-substituted-1.3. 4-thiadiazoles (5a-
g) and 2-substituted-1, 3, 4-oxadiazoles (6a-g) have been synthesized. Twenty-one of the
newly synthesized compounds were tested against various bacteria, fungi, yeast species
and virus. In addition, we have replaced the carboxylic acid group of diflunisal with
heterocycles and the anti-inflammatory activity of heterocycles reported here. Compound …
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