Systematic humanization of the yeast cytoskeleton discerns functionally replaceable from divergent human genes
Genetics, 2020•academic.oup.com
… To determine functional redundancy and divergence of duplicated human genes, we
systematically humanized the yeast actin, myosin, tubulin, and septin genes, testing ∼81% of
human cytoskeletal genes across seven gene families for their ability to complement a growth
defect induced by inactivation or deletion of the corresponding yeast ortholog. In five of seven
families—all but α-tubulin and light myosin, we found at least one human gene capable of
complementing loss of the … To understand the extent to which human cytoskeletal genes …
systematically humanized the yeast actin, myosin, tubulin, and septin genes, testing ∼81% of
human cytoskeletal genes across seven gene families for their ability to complement a growth
defect induced by inactivation or deletion of the corresponding yeast ortholog. In five of seven
families—all but α-tubulin and light myosin, we found at least one human gene capable of
complementing loss of the … To understand the extent to which human cytoskeletal genes …
Abstract
To understand the extent of functional divergence across duplicated genes in core eukaryotic systems, Garge et al. systematically tested ∼81% of human orthologs....
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