Systemic inflammatory mediators are effective biomarkers for predicting adverse outcomes in Clostridioides difficile infection
MG Dieterle, R Putler, DA Perry, A Menon… - MBio, 2020 - Am Soc Microbiol
Clostridioides difficile infection (CDI) can result in severe disease and death, with no
accurate models that allow for early prediction of adverse outcomes. To address this need,
we sought to develop serum-based biomarker models to predict CDI outcomes. We
prospectively collected sera≤ 48 h after diagnosis of CDI in two cohorts. Biomarkers were
measured with a custom multiplex bead array assay. Patients were classified using IDSA
severity criteria and the development of disease-related complications (DRCs), which were …
accurate models that allow for early prediction of adverse outcomes. To address this need,
we sought to develop serum-based biomarker models to predict CDI outcomes. We
prospectively collected sera≤ 48 h after diagnosis of CDI in two cohorts. Biomarkers were
measured with a custom multiplex bead array assay. Patients were classified using IDSA
severity criteria and the development of disease-related complications (DRCs), which were …
[PDF][PDF] Systemic inflammatory mediators are effective biomarkers for predicting adverse outcomes in Clostridioides difficile infection. mBio 11: e00180-20
MG Dieterle, R Putler, DA Perry, A Menon… - 2020 - academia.edu
Clostridioides difficile infection (CDI) can result in severe disease and death, with no
accurate models that allow for early prediction of adverse outcomes. To address this need,
we sought to develop serum-based biomarker models to predict CDI outcomes. We
prospectively collected sera 48 h after diagnosis of CDI in two cohorts. Biomarkers were
measured with a custom multiplex bead array assay. Patients were classified using IDSA
severity criteria and the development of diseaserelated complications (DRCs), which were …
accurate models that allow for early prediction of adverse outcomes. To address this need,
we sought to develop serum-based biomarker models to predict CDI outcomes. We
prospectively collected sera 48 h after diagnosis of CDI in two cohorts. Biomarkers were
measured with a custom multiplex bead array assay. Patients were classified using IDSA
severity criteria and the development of diseaserelated complications (DRCs), which were …
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