… classical functions of TERT involving activation of the Wingless-… of p53 and PGC1a/b target
genes, enabling us to identify a … occurs in several neurological diseases of aging, such as …

… was involved in TERT-mediated aberrant DNA methylation and … -cancer hallmarks via its
telomere lengthening-dependent … epigenetic state, however, shortened telomeres in aged cells …

… available literature about primary aging hallmarks and their roles in … stress-induced DNA
methylation and DNA methylation-directed … , and can be used as a new drug target to treat AD. …

… in aberrant DNA methylation, AKT activation and many other … to multiple cancer hallmarks
by regulating DNA methylation … , and physiological aging, while the aberrant TERT gene de-…

… infinitely, which is an essential cancer hallmark (5). Cancer-… GABPB1 stimulate TERT
transcription, but several lines of … Indeed, DNA methylation inhibitors and histone demethylase …

… Replicative immortality is a hallmark of cancer cells … mechanism of telomerase activation in
multiple cancers. However… within THOR, the average DNA methylation of the CpG sites at the …

… of cancers can be influenced by several aging hallmarks. Finally, we will … in their DNA
methylation patterns.As in the case of … Overall, the activation or upregulation of AMPK and several …

… Epigenetic modification includes DNA methylation, post-… mitochondria in aging, the
overlapping phenotypes of TERT, PGC… biological process of multiple aging markers, further …

… , and activated lymphocytes, delay senescence by activating the … Methylation profiles of
the TERC and TERT genes did not … There are several models based on DNA methylation that …

… in incidence during the last several decades, GC is the fourth … The TERT promoter is correlated
with hypoacetyled core … possibly play a role in aging and age-related diseases. TERRA is …