Neurogenesis decreases during aging causing a progressive cognitive decline but it is still
controversial whether proliferation defects in neurogenic niches result from a loss of neural
stem cells or from an impairment of their progression through the cell cycle. Using an
accurate fluorescence-activated cell sorting technique, we show that the pool of neural stem
cells is maintained in the subventricular zone of middle-aged mice while they have a
reduced proliferative potential eventually leading to the subsequent decrease of their …

Neurogenesis decreases during aging causing a progressive cognitive decline but it is still
controversial whether proliferation defects in neurogenic niches result from a loss of neural
stem cells or from an impairment of their progression through the cell cycle. By using an
accurate FACS technique, we show that the pool of neural stem cells is maintained in the
subventricular zone of middle-aged mice while they have a reduced proliferative potential
eventually leading to the subsequent decrease of their progeny. In addition, we demonstrate …