TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation
T Olsen, R Rismo, G Cui, R Goll, I Christiansen… - Cytokine, 2011 - Elsevier
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) have been associated
with a T helper1 (TH1) and a TH2 cytokine profile, respectively. Recently, a TH17 lineage
has been introduced, but their role in the inflammation of CD and UC is not fully understood.
AIM: To characterize the cytokines directing the TH17 cells and their interactions with TH1
cells in the mucosa of untreated patients with CD and UC. METHOD: Seventy-nine patients
with untreated UC, 32 patients with untreated CD and 23 controls with no signs of colon …
with a T helper1 (TH1) and a TH2 cytokine profile, respectively. Recently, a TH17 lineage
has been introduced, but their role in the inflammation of CD and UC is not fully understood.
AIM: To characterize the cytokines directing the TH17 cells and their interactions with TH1
cells in the mucosa of untreated patients with CD and UC. METHOD: Seventy-nine patients
with untreated UC, 32 patients with untreated CD and 23 controls with no signs of colon …
TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation. P-016.
T Olsen, R Rismo, G Cui, R Goll… - Inflammatory Bowel …, 2011 - academic.oup.com
Background Crohn's disease (CD) has been associated with a T helper (TH) cytokine profile
and Ulcerative colitis (UC) has been associated with a TH2 cytokine profile (1). Recently,
TH17 cells have been introduced as a third and new lineage of T cells but its role in
mediating the inflammation of CD and UC is not fully understood. Aim To characterize the
cytokines influencing the activity of the TH17 cells and the interactions to TH1 cells in
inflamed untreated in patients with CD and UC and in patients with no sign of organic colon …
and Ulcerative colitis (UC) has been associated with a TH2 cytokine profile (1). Recently,
TH17 cells have been introduced as a third and new lineage of T cells but its role in
mediating the inflammation of CD and UC is not fully understood. Aim To characterize the
cytokines influencing the activity of the TH17 cells and the interactions to TH1 cells in
inflamed untreated in patients with CD and UC and in patients with no sign of organic colon …
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