Abstract Toll‐like receptors 2 (TLR2) and 4 (TLR4) are present in the plasma membrane of
skeletal muscle cells where their functions remain incompletely resolved. They can bind
various extracellular ligands, such as FSL‐1, lipopolysaccharide (LPS) and/or palmitic acid
(PA). We have investigated the link between PA, TLR2/4 and ribosomal S6 kinase 1 (S6K1)
in C2C12 myotubes. Incubation with agonists of either TLR2 or TLR4, and with a high
concentration of PA, increased S6K1 phosphorylation. Canonical upstream kinases of S6K1 …

Abstract Toll-like receptors 2 (TLR2) and 4 (TLR4) are present in the plasma membrane of
skeletal muscle cells where their functions remain incompletely resolved. They are able to
bind various extra-cellular ligands, such as FSL-1, lipopolysaccharide (LPS) and/or palmitic
acid (PA). The purpose of this study was to investigate the link between PA, TLR2/4, and
ribosomal S6 kinase 1 (S6K1) in C2C12 myotubes. Incubation with agonists of either TLR2
or TLR4, as well as incubation with high concentration of PA, led to an increase in S6K1 …