突触修剪过程中小胶质细胞介导巡视和吞噬作用的分子机制

A Huo, J Wang, Q Li, M Li, Y Qi, Q Yin, W Luo… - 中国神经再生研究 …, 2024 - sjzsyj.com.cn
complement-mediated microglial phagocytosis in synapse … The deletion of TREM2 results
in increased synapse density … complement inhibitor SRPX2 protects against complement

小胶质细胞对突触可塑性和学习记忆的调节

J Cornell, S Salinas, HY Huang, M Zhou - 中国神经再生研究(英文版), 2022 - sjzsyj.com.cn
Complement proteins specifically localize and bind to … mainly via the complement-mediated
synaptic elimination. … , indicating that TREM2 expression negatively affects synaptic plasticity …

补体系统激活参与阿尔茨海默病的研究进展.

慕静然, 骆延, 梁璇, 徐陶, 曾俊伟… - Tianjin Medical …, 2024 - search.ebscohost.com
complement can bind to cell membrane receptors and regulate downstream signals. Therefore,
inhibiting complement … ,需要C1q与髓系细胞触发受体2 (TREM2)和ApoE 共同参与完成[29],…

缺血性脑卒中后小胶质细胞吞噬作用的研究进展

汪恒, 孙浩, 廖红 - 中国药科大学学报, 2023 - jcpu.cpu.edu.cn
… 据最新研究报道,S1P 可以作为TREM2 受体 的内源性配体,促进小胶… prevents complement C1
binding and comple⁃ ment … polarization and complement-mediated synapse loss to restore …