Members of the triggering receptor expressed on myeloid cells (TREM) family are
associated with atherosclerosis risk and progression. TREML4 is upregulated in the early
phase of acute coronary syndrome. We investigated the relationship between the mRNA
expression of 13 genes in blood leukocytes, TREML4 polymorphisms, and coronary artery
lesion extension (Friesinger index) in patients with coronary artery disease (CAD)(n= 137).
TREML4 rs2803495 (A> G) and rs2803496 (T> C) variants and leukocyte mRNA expression …

Results Clinical and biochemical laboratory data. Atherosclerotic lesion/CAD was detected
in 74.45% of subjects (n= 102). Assessment of the extent of coronary artery lesion revealed
that 38 (27.7%) patients with CAD had low lesions (FI 1–5), 41 (29.9%) had intermediate
lesions (FI 6–10), and 23 (16.8%) had major lesions (FI 11–15). Thirty-five (25.5%) subjects
had no atherosclerotic lesions and were classified as the control group (FI= 0). Clinical and
biochemical laboratory data are shown in Table 1. The mean age was higher in patients with …