Taiwankadsurins A, B, and C, Three New C19 Homolignans from Kadsura philippinensis
Three novel C19 homolignans, designated taiwankadsurins A (1), B (2), and C (3), were
isolated from the aerial parts of Taiwanese medicinal plant Kadsura philippinensis. The
structures of 1− 3, which have a 3, 4-{1 '-[(Z)-2 ''-methoxy-2 ''-oxo-ethylidene]}-pentano (2, 3-
dihydro-benzo [b] furano)-3-(2 '''-methoxycarbonyl-2 '''-hydroxy-2 ''', 3 '-epoxide) skeleton,
were determined by spectroscopic analyses, especially 2D NMR techniques (HMBC and
NOESY). Compound 2 exhibited mild cytotoxicity against human KB and Hela tumor cells.
isolated from the aerial parts of Taiwanese medicinal plant Kadsura philippinensis. The
structures of 1− 3, which have a 3, 4-{1 '-[(Z)-2 ''-methoxy-2 ''-oxo-ethylidene]}-pentano (2, 3-
dihydro-benzo [b] furano)-3-(2 '''-methoxycarbonyl-2 '''-hydroxy-2 ''', 3 '-epoxide) skeleton,
were determined by spectroscopic analyses, especially 2D NMR techniques (HMBC and
NOESY). Compound 2 exhibited mild cytotoxicity against human KB and Hela tumor cells.
Three novel C19 homolignans, designated taiwankadsurins A (1), B (2), and C (3), were isolated from the aerial parts of Taiwanese medicinal plant Kadsura philippinensis. The structures of 1−3, which have a 3,4-{1‘-[(Z)-2‘ ‘-methoxy-2‘ ‘-oxo-ethylidene]}-pentano(2,3-dihydro-benzo[b]furano)-3-(2‘ ‘‘-methoxycarbonyl-2‘ ‘‘-hydroxy-2‘ ‘‘,3‘-epoxide) skeleton, were determined by spectroscopic analyses, especially 2D NMR techniques (HMBC and NOESY). Compound 2 exhibited mild cytotoxicity against human KB and Hela tumor cells.
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