Tamoxifen and mifepriston modulate nicotine induced conditioned place preference in female rats

G Yararbas, S Pogun - Brain Research Bulletin, 2011 - Elsevier
An increasing number of studies suggest that nicotine/tobacco addiction is modulated by
ovarian hormones. The levels of estrogen and progesterone appear to be important in the
success of quit attempts and smoking cessation. In women smokers with the diagnosis or
risk of breast cancer, the estrogen receptor modulator tamoxifen (TAM) is widely used, and
even though the detrimental health effects of smoking are known, this vulnerable group has
difficulty quitting and continues to smoke. The current study tested the effect of the estrogen …
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