… gene expression changes in Mtb that resemble those induced by HU deficiency. Our results
indicate that HU is a potential target for the development of therapies against tuberculosis. …

… mycobacterial genes. The virtual screening used in this study to find new potential inhibitors
that target Mtb nucleoid-associated proteins … as potential novel targets for these NAPs from a …

… class of DNAinteraction inhibitors and HU as a druggable target, more so because … ,
targeting the nucleoid associated protein HU in Mtb can strategize design of new anti-mycobacterial …

… organisms HU like proteins are essential, which makes them a promising drug target for
infectious pathogens, which encouraged our group to design structure-based inhibitors against …

… Among the nucleoid-associated proteins (NAPs), HU is the most conserved in … Targeting
Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors…

… inhibitor of Lsr2-DNA complex formation, was found to intercalate into the DNA. The resulting
toxic effect on both its target M… IHF belongs to the HU family of DNA binding proteins due to …

… The ability of Mycobacterium tuberculosis to adapt to the … The IHF/HU fold is highly
conserved and is able to induce a … A structure-based approach aimed at designing HupB-DNA …

… targeting of HupB with SD1, a known small molecule inhibitor, … a highly promising therapeutic
target especially for potential … HupB is an Mtb-encoded HU-like protein of E. coli and a …

… is the most abundant nucleoid-associated protein in bacteria, … In most other bacteria, including
Mycobacterium tuberculosis… , using structure-based drug design, inhibitors targeting the α-…

… HU, a major NAP of Mycobacterium tuberculosis specifically stimulates the DNA relaxation
ability of mycobacterial … achieved by HU, and such sites are likely targets for TopoI inhibition. …