… (LXR) regulates lipid, carbohydrate metabolism in various malignancies including mammary
carcinogenesis (MC). In this study Taxifolin (… the agonistic binding of TAX on LXR receptor …

… off-target binding, improved drug-likeness, as well as enhanced binding to the therapeutic
… Liver X receptors (LXR α & β), an important target for cancer chemotherapy, associated with …

… -α mRNA were increased after stimulation with LPS. The increased expression of IL-1β and
TNF-α … As shown in Figure 5, the LXRα mRNA is effectively induced after treatment with LK-…

… induces liver X receptor (LXR)α-mediated intracellular lipid … kaempferol, the flavanone taxifolin
and the flavone apigenin on … Similarly, PI3K/AKT-sterol regulatory element binding protein …

… Furthermore, TAX reduced the expression of ATP-binding cassette subfamily B member 1
(ABCB1) and the function of P-glycoprotein (P-gp) via uncompetitive inhibition of rhodamine …

… For instance, molecular docking analysis and in vivo results established a high binding
affinity between TAX and Nrf2, β-catenin, and TNF-α as target proteins. Therefore, TAX can …

… , LXR functions as lowering blood lipid by binding to LXR response … binding free energy of
LXR between wild type and mutations. Each residue in mutations was changed into standard α…

… of phosphorylated Nrf2 into the nucleus, binding to antioxidant response elements (ARE), …
injury by reducing serum TNF-α and IL-6 levels, inhibiting IκB-α phosphorylation, NF-κB/p65 …

Silymarin is a hepatoprotective mixture of flavonolignans and flavonoids extracted from the
seeds of milk thistle (Silybum marianum L. Gaertn). This study investigates the effect of major …

… The o-quinone structure in the B-ring of TAX binds to Aβ 42 via lysine (Lys) 16 and Lys 28
residues via covalent binding. The TAX-Aβ 42 complex suppresses Aβ 42 fibril formation as …