Telomerase-dependent 3′ G-strand overhang maintenance facilitates GTBP1-mediated telomere protection from misplaced homologous recombination
At the 3′-end of telomeres, single-stranded G-overhang telomeric repeats form a stable T-
loop. Many studies have focused on the mechanisms that generate and regulate the length
of telomere 3′ G-strand overhangs, but the roles of G-strand overhang length control in
proper T-loop formation and end protection remain unclear. Here, we examined functional
relationships between the single-stranded telomere binding protein GTBP1 and G-strand
overhang lengths maintained by telomerase in tobacco (Nicotiana tabacum). In tobacco …
loop. Many studies have focused on the mechanisms that generate and regulate the length
of telomere 3′ G-strand overhangs, but the roles of G-strand overhang length control in
proper T-loop formation and end protection remain unclear. Here, we examined functional
relationships between the single-stranded telomere binding protein GTBP1 and G-strand
overhang lengths maintained by telomerase in tobacco (Nicotiana tabacum). In tobacco …
Telomerase-dependent 3′ G-strand overhang maintenance facilitates GTBP1-mediated telomere protection from misplaced homologous recombination.
LYW Lee YongWoo, KWT Kim WooTaek - 2013 - cabidigitallibrary.org
At the 3′-end of telomeres, single-stranded G-overhang telomeric repeats form a stable T-
loop. Many studies have focused on the mechanisms that generate and regulate the length
of telomere 3′ G-strand overhangs, but the roles of G-strand overhang length control in
proper T-loop formation and end protection remain unclear. Here, we examined functional
relationships between the single-stranded telomere binding protein GTBP1 and G-strand
overhang lengths maintained by telomerase in tobacco (Nicotiana tabacum). In tobacco …
loop. Many studies have focused on the mechanisms that generate and regulate the length
of telomere 3′ G-strand overhangs, but the roles of G-strand overhang length control in
proper T-loop formation and end protection remain unclear. Here, we examined functional
relationships between the single-stranded telomere binding protein GTBP1 and G-strand
overhang lengths maintained by telomerase in tobacco (Nicotiana tabacum). In tobacco …
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