There has been a growing public concern on the subject of exposure to electromagnetic field (EMF) radiation. Additionally, the actual discussions have been focused on the radio frequency (RF) area arising from the number of devices in active use. In consequence of the public interest and the increasing number of devices, heating (thermal) effects of EMFs have become a field of study for scientists. In this study, an experimental research, among various methods, is carried out to clarify current challenges to investigate the effect of EMF. The purpose of this paper is to present an effective experimental setup and observe the temperature distribution in the head tissue equivalent liquid (HEL) exposed to EMF. In order to achieve these objectives, a HEL is prepared and the HEL is exposed to EMF with different strengths from different distances. Resulting temperature distribution in the HEL is observed by a sensitive thermal probe at different depths. Thus, one of the most comprehensive studies in the literature is presented in this paper. Through application of high powered EMF, examination of continuous exposure and testing a wide range of experimental variations, this study makes contribution to other studies in the literature.