Temporal Sequence Learning in People With Schizophrenia
Background A core feature of schizophrenia (SZ) is relational memory dysfunction. This
impairment may relate to a difficulty organizing items within a temporal context. Learning of
items in a temporal context is accompanied by speeded reaction times (RT)(ie, RT
facilitation) and hippocampal activation, which we hypothesized to be reduced in SZ.
Methods During fMRI, healthy controls (HC) and SZ were shown 3 types of previously
learned sequences: fixed (same items, same order), random (same items, different order) …
impairment may relate to a difficulty organizing items within a temporal context. Learning of
items in a temporal context is accompanied by speeded reaction times (RT)(ie, RT
facilitation) and hippocampal activation, which we hypothesized to be reduced in SZ.
Methods During fMRI, healthy controls (HC) and SZ were shown 3 types of previously
learned sequences: fixed (same items, same order), random (same items, different order) …
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