Prolonged periods of tissue compression may lead to the development of pressure ulcers,
some of which may originate in, for example, skeletal muscle tissue and progress
underneath intact skin, representing deep tissue injury. Their etiology is multifactorial and
the interaction between individual causal factors and their relative importance remain
unknown. The present study addressed the relative contributions of deformation and
ischemic factors to altered metabolism and viability. Engineered muscle tissue was prepared …

Temporal differences in the influence of ischemic factors and deformation on the metabolism
of engineered skeletal muscle. J Appl Physiol 103: 464–473, 2007. First published April 19,
2007; doi: 10.1152/japplphysiol. 01374.2006.—Prolonged periods of tissue compression
may lead to the development of pressure ulcers, some of which may originate in, for
example, skeletal muscle tissue and progress underneath intact skin, representing deep
tissue injury. Their etiology is multifactorial and the interaction between individual causal …