A comparison was made between six turbulence models and experimental temperature profiles for the turbulent natural convection in a tilted open cubic cavity. The experimental setup consists of a cubic cavity of 1 m by side with one vertical wall receiving a constant and uniform heat flux, whereas the remaining walls are thermally insulated. The thermal fluid is air and the aperture is facing the heated wall. The temperature profiles were obtained at different heights and depths and each one consists of 10 positions inside the cavity. A commercial computational fluid dynamic software was used for the simulation and different turbulence models of k-ε_t and k-ω families were evaluated against experimental data. The lowest absolute average percentage difference for the experimental and numerical temperature profiles was for the rk-ε_t model and the highest was for the sk-ω model.