Glioblastoma (GBM), one of the most malignant human neoplasias, responds poorly to
current treatment modalities, with temozolomide (TMZ) being the drug most frequently used
for its treatment. Tetra-O-methyl Nordihydroguaiaretic Acid (M4N) is a global transcriptional
repressor of genes dependent on the Sp1 transcription factor, such as Survivin and Cdk1. In
the present study we evaluated the gene expression of Survivin, its spliced variants and
Cdk1 in GBM samples and cell lines. Moreover, we investigated the effects of M4N …

Introduction: Survivin, an inhibitor of apoptosis protein and key regulator of mitosis, is up-
regulated in a variety of cancers and is often associated with a worse prognosis.
Terameprocol down-regulates the Sp1-mediated transcription of survivin and Cdk1, which is
important for cell cycle progression and many other proteins. Survivin inhibition has
previously been shown to result in the induction of apoptosis and radiosensitization.
Methods: This study examined the effects of terameprocol administration on survivin …