The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators
DCC Wai, TN Szyszka, AE Campbell, C Kwong… - Journal of Biological …, 2018 - ASBMB
Members of the bromodomain and extra-terminal domain (BET) family of proteins
(bromodomain-containing (BRD) 2, 3, 4, and T) are widely expressed and highly conserved
regulators of gene expression in eukaryotes. These proteins have been intimately linked to
human disease, and more than a dozen clinical trials are currently underway to test BET-
protein inhibitors as modulators of cancer. However, although it is clear that these proteins
use their bromodomains to bind both histones and transcription factors bearing acetylated …
(bromodomain-containing (BRD) 2, 3, 4, and T) are widely expressed and highly conserved
regulators of gene expression in eukaryotes. These proteins have been intimately linked to
human disease, and more than a dozen clinical trials are currently underway to test BET-
protein inhibitors as modulators of cancer. However, although it is clear that these proteins
use their bromodomains to bind both histones and transcription factors bearing acetylated …