The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism
Y Arimura, H Tachiwana, H Takagi, T Hori… - Nature …, 2019 - nature.com
Centromeric nucleosomes are composed of the centromere-specific histone H3 variant
CENP-A and the core histones H2A, H2B, and H4. To establish a functional kinetochore,
histone H4 lysine-20 (H4K20) must be monomethylated, but the underlying mechanism has
remained enigmatic. To provide structural insights into H4K20 methylation, we here solve
the crystal structure of a nucleosome containing an H3. 1-CENP-A chimera, H3. 1CATD,
which has a CENP-A centromere targeting domain and preserves essential CENP-A …
CENP-A and the core histones H2A, H2B, and H4. To establish a functional kinetochore,
histone H4 lysine-20 (H4K20) must be monomethylated, but the underlying mechanism has
remained enigmatic. To provide structural insights into H4K20 methylation, we here solve
the crystal structure of a nucleosome containing an H3. 1-CENP-A chimera, H3. 1CATD,
which has a CENP-A centromere targeting domain and preserves essential CENP-A …
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