The E3 ubiquitin ligase SCFFBXL14 complex stimulates neuronal differentiation by targeting the Notch signaling factor HES1 for proteolysis
Molecular oscillators are important cellular regulators of, for example, circadian clocks,
oscillations of immune regulators, and short-period (ultradian) rhythms during embryonic
development. The Notch signaling factor HES1 (hairy and enhancer of split 1) is a well-
known repressor of proneural genes, and HES1 ultradian oscillation is essential for keeping
cells in an efficiently proliferating progenitor state. HES1 oscillation is driven by both
transcriptional self-repression and ubiquitin-dependent proteolysis. However, the E3 …
oscillations of immune regulators, and short-period (ultradian) rhythms during embryonic
development. The Notch signaling factor HES1 (hairy and enhancer of split 1) is a well-
known repressor of proneural genes, and HES1 ultradian oscillation is essential for keeping
cells in an efficiently proliferating progenitor state. HES1 oscillation is driven by both
transcriptional self-repression and ubiquitin-dependent proteolysis. However, the E3 …