Researches on the effects of the Covid-19 pandemic continues to increase all over the world. International organizations also support these researches and prioritize studies in this field. The main purpose here is to proactively construct the measures for the new world order by precisely determining the effects of the pandemic. Meeting the sustainable development and ever-increasing human needs in the world depends on maintaining the high level of innovation and internal entrepreneurship (intrapreneurship) activities in all kinds of institutions and organizations. Factors affecting intrapreneurship are generally linked to the internal dynamics (factors) of the organization, and studies have focused on this area. However, studies on the effects of environmental factors also show that intrapreneurship is also predicted by these factors. In this study, the effect of the health illness (Covid-19) factor, which is considered as a crisis factor among environmental factors, on the intrapreneurship attitude and behavior of employees was tried to be determined with an empirical study with 203 participants. The findings obtained show that the Covid-19 pandemic significantly affects intrapreneurship, and this effect differs according to some control variables.