The Finland–United States investigation of non–insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose …
S Ghosh, RM Watanabe, TT Valle, ER Hauser… - The American Journal of …, 2000 - cell.com
We performed a genome scan at an average resolution of 8 cM in 719 Finnish sib pairs with
type 2 diabetes. Our strongest results are for chromosome 20, where we observe a weighted
maximum LOD score (MLS) of 2.15 at map position 69.5 cM from pter and secondary
weighted LOD-score peaks of 2.04 at 56.5 cM and 1.99 at 17.5 cM. Our next largest MLS is
for chromosome 11 (MLS= 1.75 at 84.0 cM), followed by chromosomes 2 (MLS= 0.87 at 5.5
cM), 10 (MLS= 0.77 at 75.0 cM), and 6 (MLS= 0.61 at 112.5 cM), all under an additive model …
type 2 diabetes. Our strongest results are for chromosome 20, where we observe a weighted
maximum LOD score (MLS) of 2.15 at map position 69.5 cM from pter and secondary
weighted LOD-score peaks of 2.04 at 56.5 cM and 1.99 at 17.5 cM. Our next largest MLS is
for chromosome 11 (MLS= 1.75 at 84.0 cM), followed by chromosomes 2 (MLS= 0.87 at 5.5
cM), 10 (MLS= 0.77 at 75.0 cM), and 6 (MLS= 0.61 at 112.5 cM), all under an additive model …
The Finland–United States investigation of non–insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related …
RM Watanabe, S Ghosh, CD Langefeld, TT Valle… - The American Journal of …, 2000 - cell.com
Type 2 diabetes mellitus is a complex disorder encompassing multiple metabolic defects.
We report results from an autosomal genome scan for type 2 diabetes–related quantitative
traits in 580 Finnish families ascertained for an affected sibling pair and analyzed by the
variance components-based quantitative-trait locus (QTL) linkage approach. We analyzed
diabetic and nondiabetic subjects separately, because of the possible impact of disease on
the traits of interest. In diabetic individuals, our strongest results were observed on …
We report results from an autosomal genome scan for type 2 diabetes–related quantitative
traits in 580 Finnish families ascertained for an affected sibling pair and analyzed by the
variance components-based quantitative-trait locus (QTL) linkage approach. We analyzed
diabetic and nondiabetic subjects separately, because of the possible impact of disease on
the traits of interest. In diabetic individuals, our strongest results were observed on …
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