The PTEX Pore Component EXP2 Is Important for Intrahepatic Development during the Plasmodium Liver Stage
During vertebrate infection, obligate intracellular malaria parasites develop within a
parasitophorous vacuole, which constitutes the interface between the parasite and its
hepatocyte or erythrocyte host cells. To traverse this barrier, Plasmodium spp. utilize a dual-
function pore formed by EXP2 for nutrient transport and, in the context of the PTEX
translocon, effector protein export across the vacuole membrane. While critical to blood-
stage survival, less is known about EXP2/PTEX function in the liver stage, although major …
parasitophorous vacuole, which constitutes the interface between the parasite and its
hepatocyte or erythrocyte host cells. To traverse this barrier, Plasmodium spp. utilize a dual-
function pore formed by EXP2 for nutrient transport and, in the context of the PTEX
translocon, effector protein export across the vacuole membrane. While critical to blood-
stage survival, less is known about EXP2/PTEX function in the liver stage, although major …
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