The RNA Pol II sub-complex hsRpb4/7 is required for viability of multiple human cell lines
Y Zhao, KKC Li, KP Ng, CH Ng, KAW Lee - Protein & cell, 2012 - academic.oup.com
The evolutionarily conserved RNA Polymerase II Rpb4/7 sub-complex has been thoroughly
studied in yeast and impacts gene expression at multiple levels including transcription,
mRNA processing and decay. In addition Rpb4/7 exerts differential effects on gene
expression in yeast and Rpb4 is not obligatory for yeast (S. cerevisiae) survival. Specialised
roles for human (hs) Rpb4/7 have not been extensively described and we have probed this
question by depleting hsRpb4/7 in established human cell lines using RNA interference. We …
studied in yeast and impacts gene expression at multiple levels including transcription,
mRNA processing and decay. In addition Rpb4/7 exerts differential effects on gene
expression in yeast and Rpb4 is not obligatory for yeast (S. cerevisiae) survival. Specialised
roles for human (hs) Rpb4/7 have not been extensively described and we have probed this
question by depleting hsRpb4/7 in established human cell lines using RNA interference. We …
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