The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation
R Melero, N Hug, A López-Perrote, A Yamashita… - Nature …, 2016 - nature.com
Nonsense-mediated decay (NMD) is a messenger RNA quality-control pathway triggered by
SMG1-mediated phosphorylation of the NMD factor UPF1. In recent times, the RNA helicase
DHX34 was found to promote mRNP remodelling, leading to activation of NMD. Here we
demonstrate the mechanism by which DHX34 functions in concert with SMG1. DHX34
comprises two distinct structural units, a core that binds UPF1 and a protruding carboxy-
terminal domain (CTD) that binds the SMG1 kinase, as shown using truncated forms of …
SMG1-mediated phosphorylation of the NMD factor UPF1. In recent times, the RNA helicase
DHX34 was found to promote mRNP remodelling, leading to activation of NMD. Here we
demonstrate the mechanism by which DHX34 functions in concert with SMG1. DHX34
comprises two distinct structural units, a core that binds UPF1 and a protruding carboxy-
terminal domain (CTD) that binds the SMG1 kinase, as shown using truncated forms of …
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