The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A …
C Van Rechem, JC Black, T Abbas, A Allen… - Journal of Biological …, 2011 - ASBMB
Chromatin-modifying enzymes play a fundamental role in regulating chromatin structure so
that DNA replication is spatially and temporally coordinated. For example, the lysine
demethylase 4A/Jumonji domain-containing 2A (KDM4A/JMJD2A) is tightly regulated during
the cell cycle. Overexpression of JMJD2A leads to altered replication timing and faster S
phase progression. In this study, we demonstrate that degradation of JMJD2A is regulated
by the proteasome. JMJD2A turnover is coordinated through the SKP1-Cul1-F-box ubiquitin …
that DNA replication is spatially and temporally coordinated. For example, the lysine
demethylase 4A/Jumonji domain-containing 2A (KDM4A/JMJD2A) is tightly regulated during
the cell cycle. Overexpression of JMJD2A leads to altered replication timing and faster S
phase progression. In this study, we demonstrate that degradation of JMJD2A is regulated
by the proteasome. JMJD2A turnover is coordinated through the SKP1-Cul1-F-box ubiquitin …
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