Abstract Background and Objective Quadpill, a single pill containing a quadruple
combination of quarter doses of four antihypertensive agents, has been investigated for
hypertension treatment. This meta-analysis aims to evaluate the safety and efficacy of
quadpill for hypertension management. Methods We conducted a systematic review and
meta-analysis synthesizing randomized controlled trials evaluating quadpill versus
monotherapy or placebo in patients with hypertension, which were retrieved by …

Background Hypertension is a significant healthcare burden, with an average global
prevalence of 1.28 billion adults aged between 30-79 years old. Using antihypertensive
drug combinations is considered more effective in controlling elevated blood pressure than
monotherapy; however, psychological factors of the patients and the physicians' caution
from the drugs' adverse effects are still barriers against antihypertensive drug combinations.
Quadpill, a single pill containing a quadruple combination of quarter doses of four …