Abstract Objectives/Hypothesis: This study aimed to assess the clinical relevance of
contamination of nasal irrigation bottles in patients with recalcitrant chronic rhinosinusitis
(CRS). Secondary investigations to identify the presence of bacterial biofilms on the inner
surface of the bottles and to assess different sterilization methods were also undertaken.
Study Design: Prospective, observational. Methods: Eleven patients with recalcitrant CRS
who were already using nasal irrigation as part of their treatment regimen were examined …

The primary goal of this prospective, observational study was to assess the importance of
contamination of nasal irrigation bottles in recalcitrant chronic rhinosinusitis (CRS) patients.
Furthermore, the study sought to identify the presence of biofilms inside irrigation bottles as
well as different sterilization techniques. The use of nasal irrigation is a long-standing,
effective adjunct therapy in the management of CRS. Additionally, low-pressure, large-
volume rinses such as the commonly used Neil Sinus Rinse have been proven more …