The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model
R Abdelnabi, CS Foo, SJF Kaptein, X Zhang… - …, 2021 - thelancet.com
Abstract Background Favipiravir and Molnupiravir, orally available antivirals, have been
reported to exert antiviral activity against SARS-CoV-2. First efficacy data have been recently
reported in COVID-19 patients. Methods We here report on the combined antiviral effect of
both drugs in a SARS-CoV-2 Syrian hamster infection model. The infected hamsters were
treated twice daily with the vehicle (the control group) or a suboptimal dose of each
compound or a combination of both compounds. Findings When animals were treated with a …
reported to exert antiviral activity against SARS-CoV-2. First efficacy data have been recently
reported in COVID-19 patients. Methods We here report on the combined antiviral effect of
both drugs in a SARS-CoV-2 Syrian hamster infection model. The infected hamsters were
treated twice daily with the vehicle (the control group) or a suboptimal dose of each
compound or a combination of both compounds. Findings When animals were treated with a …
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