[HTML][HTML] The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targets

H Endisha, J Rockel, I Jurisica, M Kapoor - JCI insight, 2018 - ncbi.nlm.nih.gov
The disabling degenerative disease osteoarthritis (OA) is prevalent among the global
population. Articular cartilage degeneration is a central feature of OA; therefore, a better
understanding of the mechanisms that maintain cartilage homeostasis is vital for developing
effective therapeutic interventions. MicroRNAs (miRs) modulate cell signaling pathways and
various processes in articular cartilage via posttranscriptional repression of target genes. As
dysregulated miRs frequently alter the homeostasis of articular cartilage, modulating select …

[引用][C] The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targets, JCI Insight 3 (2018)

H Endisha, J Rockel, I Jurisica, M Kapoor - Article e121630
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