The effect of 13C enrichment in the glassing matrix on dynamic nuclear polarization of [1-13C] pyruvate
Physics in Medicine & Biology, 2011•iopscience.iop.org
Dimethyl sulfoxide (DMSO) can effectively form a glassy matrix necessary for dynamic
nuclear polarization (DNP) experiments. We tested the effects of 13 C enrichment in DMSO
on DNP of [1-13 C] pyruvate doped with trityl radical OX063Me. We found that the
polarization build-up time τ of pyruvate in 13 C-labeled DMSO glassing solution is twice as
fast as the unenriched DMSO while the nuclear magnetic resonance enhancement was
unchanged. This indicates that 13 C–13 C spin diffusion is a limiting factor in the kinetics of …
nuclear polarization (DNP) experiments. We tested the effects of 13 C enrichment in DMSO
on DNP of [1-13 C] pyruvate doped with trityl radical OX063Me. We found that the
polarization build-up time τ of pyruvate in 13 C-labeled DMSO glassing solution is twice as
fast as the unenriched DMSO while the nuclear magnetic resonance enhancement was
unchanged. This indicates that 13 C–13 C spin diffusion is a limiting factor in the kinetics of …
Abstract
Dimethyl sulfoxide (DMSO) can effectively form a glassy matrix necessary for dynamic nuclear polarization (DNP) experiments. We tested the effects of 13 C enrichment in DMSO on DNP of [1-13 C] pyruvate doped with trityl radical OX063Me. We found that the polarization build-up time τ of pyruvate in 13 C-labeled DMSO glassing solution is twice as fast as the unenriched DMSO while the nuclear magnetic resonance enhancement was unchanged. This indicates that 13 C–13 C spin diffusion is a limiting factor in the kinetics of DNP in this system, but it has a minimal effect on the absolute value of polarization achievable for the target.
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