The purpose of this study is to collect, process, and analyze data related to the level of liquidity and profitability of Sharia Commercial Bank in Indonesia. The population in this study consists of 10 Sharia Commercial Banks in Indonesia in the period 2014-2016. The method used in this research is descriptive and verification. Independent variables are measured by liquid asset to total asset ratio (LTA), ratio of liquid assets to deposit (LAD) and ratio of financing to deposit (FDR). While the dependent variable is measured by return on assets (ROA). Data analysis method used in this research is multiple regression. The result of this research indicates that variable of LTA and LAD have positive effect to profitability, while FDR variable and NPF variable have negative effect to profitability. The LTA LAD, FDR and NPF variables have a significant effect on profitability.