Occupational stress and turnover intention are a growing and costly concern for the hospitality industry. Drawing on Job Demands-Resources (JD-R) theory, the study developed a research model to simultaneously examine the effects of psychological capital, social capital, and human capital on occupational stress and turnover intention. A sample size of 380 hotel employees in China was used to test the proposed model using the PLS-SEM methodology. The results suggest that occupational stress plays a full mediator role between psychological capital and turnover intention, and plays a partial mediator role between relational social capital and turnover intention. Psychological capital and relational social capital were found to have relatively higher effects on occupational stress compared to other types of capital. The study extends JD-R theory by recognizing that occupational stress functions as a mediator between the three types of capital and turnover intention. The study concludes by offering a set of practical implications stemming from this research for hotel practitioners.