Background: MicroRNAs are small endogenous RNA molecules with specific expression
patterns for some diseases. Some miR-NAs were reported to be differentially expressed in
hepatitis B virus (HBV) serum. This study examines whether the serum expression levels of
miRNAs by deep sequencing can serve as biomarkers and clarify the mechanism of miRNA
with chronic hepatitis B (CH-B) infection. Methods: We detected circulating miRNAs using an
Illumina deep sequencer. 20 cases of CH-B were enrolled, and 30 cases of CH-C and …

Micro RNA s were first discovered as small endogenous RNA molecules and some viruses
have been reported to interact with host mi RNA s. By investigating mi RNA expression in
serum derived from HBV‐infected patients, we have clarified the relationship between mi
RNA expression and chronic HBV infection. Additionally, we demonstrate the use of mi RNA
s as both novel biomarkers and new therapies against HBV. We included the sera of 20
patients with chronic HBV infection, sera of 20 patients with HCV infection and sera of 10 …