This article investigates how developments in nanotechnology were framed in the British national newspaper press during a formative period in their rising public salience. Specifically, an intervention by Prince Charles in April 2003 is shown to have acted as the principal catalyst for much of the ensuing newspaper reporting over the next fifteen months. This study, in taking as its focus the operation of specific news frames, identifies a range of factors that shaped the initial terms of the subsequent debate (between both advocates and critics of nanotechnology) from one newspaper to the next during this period. The analysis suggests that the involvement of a celebrity may play a crucial role in enhancing the newsworthiness of an issue and influencing its subsequent framing in the newspaper press.