过去一年中添加的文章,按日期排序

Dissecting the Shared Genetic Architecture of Common Epilepsies With Cortical Brain Morphology

N Karadag, E Hagen, AA Shadrin… - … : Genetics, 2024 - AAN Enterprises
4 天前 - genetic architecture of epilepsies is approximately 1.5 times more polygenic than
the brain … loci of the human cerebral cortex using genetically informed brain atlases. Science. …

Identifying Alzheimer's Disease-Related Variants that Influence Transcriptional Regulation

X Zhang - 2024 - rave.ohiolink.edu
9 天前 - genetic component. This dissertation investigated the genetic architecture of AD,
focusing on how genetic … We extended the PrediXcan method, optimized X chromosome gene

Polygenic architecture of brain structure and function, behaviors, and psychopathologies in children

YY Joo, E Lee, BG Kim, G Kim, J Seo, J Cha - bioRxiv, 2024 - biorxiv.org
11 天前 - … intricate genetic networks associated with neuroimaging-derived 576 phenotypes
(IDPs). This enhances our grasp of the genetic architecture driving cerebral maturation. 577 …

Molecular mechanisms driving divergent development of the human frontal and visual cortex during prenatal development

G Epihova, DZ Epihov, D Akarca, DE Astle - bioRxiv, 2024 - biorxiv.org
18 天前 - … the brain - the frontal and visual cortex. We show that the frontal cortex exhibits
significantly higher cumulative gene … These pathways include the gene ontology terms of neuron …

GAGE-seq concurrently profiles multiscale 3D genome organization and gene expression in single cells

T Zhou, R Zhang, D Jia, RT Doty, AD Munday, D Gao… - Nature Genetics, 2024 - nature.com
20 天前 - … genome architecture and gene … mouse brain cortex and human bone marrow
CD34 + cells, GAGE-seq characterized the intricate relationships between 3D genome and gene

Multiscale characterization of cortical signatures in positive and negative schizotypy: A worldwide ENIGMA study

M Kirschner, B Hodzic-Santor, L Kennedy, JY Hansen… - medRxiv, 2024 - medrxiv.org
27 天前 - … An automated labeling system for subdividing the human cerebral cortex on MRI
scans into gyral based regions of interest. NeuroImage 31, 968–980 (2006). 52. …

Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations

SG Malone, CN Davis, Z Piserchia, MR Setzer… - medRxiv, 2024 - medrxiv.org
28 天前 - … lack of genetic correlation is due to mixed effect directions of variants shared by
AUD and BMI. Methods: We applied MiXeR, to investigate shared genetic architecture between …

[HTML][HTML] Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo

L Sportelli, DP Eisenberg, R Passiatore… - Nature …, 2024 - nature.com
34 天前 - … The genetic architecture of SCZ is complex and spans the genome 2 . Despite
evidence for aggregation of implicated genes into certain clusters 43 , characterizing the …

[引用][C] Multi-Omics Analyses of Cortical Proteome and Single Cell-Type Transcriptome Identifies Novel Drug Targets for Problematic Drinking Behavior and Alcohol …

D Rosoff, J Wagner, A Bell… - Biological …, 2024 - biologicalpsychiatryjournal.com
34 天前 - Background Integrating proteomic and transcriptomic data in brain tissue with the
genetic architectures of problematic alcohol consumption and alcohol use disorder (AUD) has …

[PDF][PDF] Schizophrenia and Cortical Plasticity: Genetic Effects in Top-Down, Organismal Dysfunction

D Larrivee - J. Brain and Neurological Disorders, 2024 - researchgate.net
39 天前 - … Extensive research in the field of cortical plasticity over the past 30 years, has
revealed that the cerebral cortex is a dynamic assembly of highly interconnected and spatially …