The Human Cytomegalovirus Chemokine vCXCL-1 Modulates Normal Dissemination Kinetics of Murine Cytomegalovirus In Vivo
JW Jackson, TJ Hancock, E LaPrade, P Dogra… - MBio, 2019 - Am Soc Microbiol
Human cytomegalovirus (HCMV) is a betaherpesvirus that is a significant pathogen within
newborn and immunocompromised populations. Morbidity associated with HCMV infection
is the consequence of viral dissemination. HCMV has evolved to manipulate the host
immune system to enhance viral dissemination and ensure long-term survival within the
host. The immunomodulatory protein vCXCL-1, a viral chemokine functioning primarily
through the CXCR2 chemokine receptor, is hypothesized to attract CXCR2+ neutrophils to …
newborn and immunocompromised populations. Morbidity associated with HCMV infection
is the consequence of viral dissemination. HCMV has evolved to manipulate the host
immune system to enhance viral dissemination and ensure long-term survival within the
host. The immunomodulatory protein vCXCL-1, a viral chemokine functioning primarily
through the CXCR2 chemokine receptor, is hypothesized to attract CXCR2+ neutrophils to …
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