In the resource-based view approach, the knowledge frontier rests on the understanding of the process of creating and recreating distinctive competences. Moreover, in spite of the importance of knowledge assets, how innovation distinctive competences are generated in organizations is still an unknown factor. This research studies the effect of introducing knowledge management programs in the development of innovation distinctive competences, using two knowledge intensive industries. We establish a conceptual delimitation of knowledge management as a directive system through a set of principles and practices. The theoretical relationships we propose are tested in an empirical study carried out in 222 firms from the Spanish biotechnology and telecommunications industries.