[HTML][HTML] The impact of non-additive genetic associations on age-related complex diseases
M Guindo-Martínez, R Amela, S Bonàs-Guarch… - Nature …, 2021 - nature.com
Genome-wide association studies (GWAS) are not fully comprehensive, as current strategies
typically test only the additive model, exclude the X chromosome, and use only one
reference panel for genotype imputation. We implement an extensive GWAS strategy,
GUIDANCE, which improves genotype imputation by using multiple reference panels and
includes the analysis of the X chromosome and non-additive models to test for association.
We apply this methodology to 62,281 subjects across 22 age-related diseases and identify …
typically test only the additive model, exclude the X chromosome, and use only one
reference panel for genotype imputation. We implement an extensive GWAS strategy,
GUIDANCE, which improves genotype imputation by using multiple reference panels and
includes the analysis of the X chromosome and non-additive models to test for association.
We apply this methodology to 62,281 subjects across 22 age-related diseases and identify …
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